国产精品国产三级国产aⅴ原创,国产一级a,久久天天,亚洲av日韩av高潮潮喷无码

您好,歡迎進(jìn)入上海力敏實(shí)業(yè)有限公司網(wǎng)站!
一鍵分享網(wǎng)站到:
您現(xiàn)在的位置:首頁 >> 產(chǎn)品中心 >> 生化試劑、抗體、血清 >> 細(xì)胞因子 >> RD 416-ml-010M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF

M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF

  • 更新時(shí)間:  2023-07-24
  • 產(chǎn)品型號:  RD 416-ml-010
  • 簡單描述
  • M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF也被稱為CSF1細(xì)胞因子,巨噬細(xì)胞的存活,增殖和分化(1)主要監(jiān)管機(jī)構(gòu)纖細(xì)說明書在產(chǎn)品詳細(xì)介紹中
詳細(xì)介紹

M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF

DESCRIPTION
Source E. coliderived
Lys33Glu262,
with an Nterminal
Met
Accession # Q3U4F9
Nterminal
Sequence
Analysis
Met
Structure / Form Disulfidelinked
homodimer
Predicted Molecular
Mass
26 kDa (monomer)
SPECIFICATIONS
SDSPAGE
29 kDa, reducing conditions
Activity Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cells. Halenbeck, R. et al. (1989)
Biotechnology 7:710.
The ED50 for this effect is typically 0.5-3 ng/mL.
Endotoxin Level <1.0 EU per 1 μg of the protein by the LAL method.
Purity >97%, by SDSPAGE
under reducing conditions and visualized by silver stain.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. See Certificate of Analysis for details.
PREPARATION AND STORAGE
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediay at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freezethaw
cycles.
l 12 months from date of receipt, 20
to 70
°C as supplied.
l 1 month, 2 to 8 °C under sterile conditions after reconstitution.
l 3 months, 20
to 70
°C under sterile conditions after reconstitution.
BACKGROUND
MCSF,
also known as CSF1,
is a fourαhelicalbundle
cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1 3).
MCSF
is also essential for the survival and proliferation of osteoclast progenitors (1, 4). MCSF
also primes and enhances macrophage killing of tumor cells and
microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). MCSF
increases during
pregnancy to support implantation and growth of the decidua and placenta (5). Sources of MCSF
include fibroblasts, activated macrophages, endometrial secretory
epithelium, bone marrow stromal cells and activated endothelial cells (1 5).
The MCSF
receptor (cfms)
transduces its pleotropic effects and mediates its
endocytosis. MCSF
mRNAs of various sizes occur (3 9).
Full length mouse MCSF
transcripts encode a 520 amino acid (aa) type I transmembrane (TM) protein with
a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two
proteolytically cleaved, secreted dimers. One is an Nand
Oglycosylated
86 kDa dimer, while the other is modified by both glycosylation and chondroitinsulfate
proteoglycan (PG) to generate a 200 kDa subunit. Although PGmodified
MCSF
can circulate, it may be immobilized by attachment to type V collagen (8). Shorter
transcripts encode M CSF
that lacks cleavage and PG sites and produces an Nglycosylated
68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7).
Although forms may vary in activity and halflife,
all contain the Nterminal
150 aa portion that is necessary and sufficient for interaction with the M CSF
receptor
(10, 11). The first 229 aa of mature mouse MCSF
shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human MCSF,
respectively (12, 13). Human MCSF
is active in the mouse, but mouse MCSF
is reported to be speciesspecific.
M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF

References:
1. Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628.
2. Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39.
3. Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125.
4. Ryan, G.R. et al. (2001) Blood 98:74.
5. Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178.
6. Nandi, S. et al. (2006) Blood 107:786.
7. Rettenmier, C.W. and M.F. Roussel (1988) Mol. Cell Biol. 8:5026.
8. Suzu, S. et al. (1992) J. Biol. Chem. 267:16812.
9. Manos, M.M. (1988) Mol. Cell. Biol. 8:5035.
10. Koths, K. (1997) Mol. Reprod. Dev. 46:31.
11. Jang, MH.
et al. (2006) J. Immunol. 177:4055.
12. DeLamarter, J.F. et al. (1987) Nucleic Acids Res. 15:2389.
13. Ladner, M.B. et al. (1988) Proc. Natl. Acad. Sci. USA 85:6706.

 

上海力敏實(shí)業(yè)有限公司代理R&D產(chǎn)品,咨詢 詳細(xì)產(chǎn)品信息


留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說明:

  • 驗(yàn)證碼:

    請輸入計(jì)算結(jié)果(填寫阿拉伯?dāng)?shù)字),如:三加四=7
一极黄片在线| 欧美日韩第一区| 开心五月停停| 上饶县| 自慰网站免费看| 亚洲欧美韩国日本综合| 性色一区二区| 色婷婷在线影院| 日本老熟妇偷情乱子伦| 风流少妇按摩来高潮| 激情图区视频区| 日韩高清一区二区黄片| 欧美日韩激情综合一区二区不卡 | 射精管理在线| 噜噜久久久噜噜| 老司机在线观看| 天天操天天色天天射| aa级片在线免费观看| 亚洲国产一区在线观看| 狼友视频网站| 四虎免费看黄片| 国产精品百科导航| 欧美日韩在线综合| 天堂AV午夜| 亚洲大尺度| 亚洲狂操色图网站| 看黄网站| 成人日韩精品| 欧美怡红院久久| 欧美乱论熟视频| 亚洲国产中文在线精品一区 | 美日韩大黄瓜视频| 成人在线黄视频| 少妇极品熟妇人妻无码| 国产在线资源自拍| 淫妇久久| 久久精品无码免费不卡| 丁香五月婷婷在线播放| 在线国产青青草| 99免费视频| 国产女人高潮大片99|